mcf-7 cells — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1768	Iriflophenone		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Iriflophenone stimulates cells proliferation in MCF-7 and T-47D human breast cancer.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T21806	HNHA		HDAC
	HNHA is an inhibitor of HDAC.		HDAC
T9244	σ1 Receptor antagonist-1		Sigma receptor
	σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.		Sigma receptor
T6588	Mitoxantrone	mitozantrone	Topoisomerase , PKC
	Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome...		Topoisomerase , PKC
T5724	Neogambogic acid	neo-gambogic acid	Apoptosis , Others , Antibacterial
	Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell li...		Apoptosis , Others , Antibacterial
T15249	Estrogen receptor modulator 1		Estrogen Receptor/ERR
	Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4...		Estrogen Receptor/ERR
T2085	PQ401	IGF-1R Inhibitor II	Apoptosis , IGF-1R
	PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).		Apoptosis , IGF-1R
T2882	Genistin	Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside	Apoptosis , Estrogen Receptor/ERR , Others
	Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities		Apoptosis , Estrogen Receptor/ERR , Others
T22288	(1E)-CFI-400437 dihydrochloride	CFI-400437 dihydrochloride	PLK
	(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.		PLK
T7786	Tryptanthrin		DNA gyrase
	Tryptanthrin is a natural DNA gyrase inhibitor.		DNA gyrase
T5882	3-Bromopyruvic acid	Hexokinase II Inhibitor II, 3-BP,Bromopyruvic acid	Apoptosis , Hexokinase , Autophagy
	3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinu...		Apoptosis , Hexokinase , Autophagy
T0158	Mitoxantrone dihydrochloride	Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride	Topoisomerase , PKC
	Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.		Topoisomerase , PKC
T19768	γ-Tocotrienol	gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol	Others
	γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.		Others
T6010	Idarubicin hydrochloride	Idamycin,4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,4-Demethoxydaunorubicin hydrochloride,Idarubicin HCl,Zavedos	Topoisomerase , Antibacterial , Autophagy , Antifungal
	Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).		Topoisomerase , Antibacterial , Autophagy , Antifungal
T72470	Estrone O-sulfamate	Estrone 3-O-sulfamate	Others
	Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS). Estrone O-sulfamate is a placental microsomal inhibitor (P.M.) with IC50 values of 18 nM. Estrone O-sulfamate showed inhibitor...		Others
T10325	ANI-7		Chk
	ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells and potently and selectively inhibits the growth of MCF-7 breast cancer cells (GI50: 0.56 μM).		Chk
T9541	CTB	Cholera Toxin B subunit	Epigenetic Reader Domain
	CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.		Epigenetic Reader Domain
T64348	Antiproliferative agent-16	Antiproliferative agent-16	Others
	Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for...		Others
TN7041	(-)-Epipodophyllotoxin		Apoptosis
	(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit...		Apoptosis
T83321	4-Demethyldeoxypodophyllotoxin		Chk
	4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.		Chk